How Often Should You Change Your Toothbrush Most people are surprised to learn that the average toothbrush contains over 700 kinds of bacteria. Fungi, viruses, and tiny microorganisms sit on the bristles of toothbrushes around the world, establishing a foundation for diseases to form. If the thought of bacteria dwelling on the toothbrush you routinely place in your mouth doesn’t peak your curiosity about changing your oral hygiene habits, think about the poor physical ...